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Mechanistically, DCN might have elicited an imbalanced inflammatory response during cardiac ischemia by suppressing the expression of anti-inflammatory genes.Ĭonclusion: Serum DCN is a novel biomarker of ACS and contributes to the increased inflammatory response in ischemic heart disease.Īcute coronary syndrome (ACS) is caused by the sudden rupture or erosion of a vulnerable atherosclerotic coronary plaque, which then results in narrowed or occluded coronary vessels and reduced blood flow to the heart ( Anderson and Morrow, 2017). Moreover, an increased serum DCN level was positively correlated with the number of white blood cells and the level of high-sensitivity C-reactive protein ( R = 0.3 and 0.11, respectively). Furthermore, the serum DCN level, after being adjusted with other cardiovascular factors, was independently associated with ACS. Results: We found that the serum DCN levels of ACS patients were elevated compared with those of the control subjects (13.59 ± 0.50 vs. Blood samples were drawn during CAG surgery to determine the serum DCN level of patients with ACS ( n = 210) and control subjects ( n = 178) using enzyme-linked immunosorbent assay. Methods: A total of 388 patients who underwent coronary angiography (CAG) in the cardiovascular center of Ruijin Hospital between June 2016 and December 2017 were enrolled in this study. Hence, we aimed to determine the relationship between serum DCN concentration and ACS. Additionally, DCN could release as secreted proteoglycan under pathological conditions. Decorin (DCN) was well-acknowledged for its effect on collagen fibrillogenesis and maintaining tissue integrity.
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It is thus important to identify ACS early in the disease course of patients using novel biomarkers for prompt management. 3Department of Cardiology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, Chinaīackground and Aims: Acute coronary syndrome (ACS) has become one of the most common causes of disability.
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2Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.1Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Lingfang Zhuang 1,2†, Yulong Ge 3†, Xiao Zong 1,2†, Qian Yang 1,2, Ruiyan Zhang 1,2, Qin Fan 1,2* and Rong Tao 1,2*